Time-Proven International Cooperation

For the period from 2014 to 2019, at “Baikal-1” complex of research reactors, specialists of NNC RK jointly with the representatives of the State Medical University of Semey, Shimane University (Japan), laboratory for Medical and ecological dosimetry and radiation safety of FSBE MRSC MH (Russia) completed a series of experiments for reactor irradiation of manganese dioxide powder and further irradiated powder effect on biological objects. The work was aimed at evaluating long-term effect of biological objects’ internal exposure to various systems of living organism.

Before the experiments, specialists of the Institute of Atomic Energy of NNC RK prepared technical basis for the experiment performance, in particular: designed and manufactured irradiation devices at reactor IVG.1M; designed and patented special devices for irradiation of experiment animals by radioactive manganese dioxide powder.

        Researchers of SMU Semey and Shimane University solved the following tasks: assessment of individual and average group dose of studied experimental groups of animals; study into peculiarities of cytogenetic defects and morphological changes in various organs of irradiated animals; comparative analysis of gene expressions for experiment animals exposed to different radiation dose, and evaluation of immunohistochemical changes in tissues, and immunochemiluminescent indexes for peripheral blood of the experiment animals.

Total of over 15 start-ups were conducted at reactor IVG-1M for the period to implement experiment series. Each experiment consisted of two stages: powder manganese dioxide irradiation by small dose (up to 100 µg) in central experimental channel of IVG.1M research reactor under the power up to 50 kW, and second stage – out-of-pile stage to irradiate experimental animals, in particular rats, by the radioactive manganese dioxide powder.